Significance of hyperferritinemia as a diagnostic and prognostic biomarker

Ferritin is a complex protein composite (iron protein) that plays the role of main intracellular iron depot in humans and animals, consisting apoferritin ferric atom composition phosphate hydroxide. The reference value ferritin women 200 μg/l, men – 300 μg/l. marker total body stores, low levels are specific for deficiency. also involved immune processes has both pro-inflammatory immunosuppressive activity. Hyperferritinemia nonspecific symptom occurs number immunoinflammatory, infectious diseases, as well during stores overload. criterion sign macrophage activation syndrome patients with systemic juvenile idiopathic arthritis, lupus erythematosus Kawasaki disease, predictive biomarker adult-onset Still's disease. High occur catastrophic antiphospholipid syndrome, pathologies such septic shock COVID-19, including multisystem inflammatory associated COVID-19. concentration an important parameter assessing activity prognosis which allows rational approach to choice therapy these patients.